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These findings parallel our observation that Prkg1SMr mice display more wakefulness in the light period (Fig. 2A, baseline).
Likewise, Thy-1 deficient mice display more severe lung fibrosis in response to an inflammatory injury than wildtype littermates.
These observations indicate that Vdr −/− mice display more severe hepatic injury after biliary-type liver disease.
Fx/Fx mice display more activity during the light portions of LD 3.5 3.5 because the circadian clock is promoting activity despite the presence of light.
Female CRF2-deficint mice display more depressive-like behaviors on the forced swim test than their male counterparts, an effect blocked by a CRF1 receptor antagonist [ 95].
We have previously shown that endogenous estrogens are sufficient to reduce CIA, because OVX mice display more severe arthritis compared with sham-operated mice [ 45].
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Adult EGF−/− mice displayed more severe lesions in response to cysteamine treatment compared with wild-type counterparts, although triple null mice were not more susceptible to dextran sulfate sodium-induced colitis, suggesting a differential role for these ligands in the injury response.
However, 24 h later, HAB mice displayed more pronounced conditioned responses to both a contextual or cued stimulus when compared with NAB mice.
For example, Grivennikov and co-workers demonstrate that Il6−/− mice exhibit decreased tumor multiplicity and load compared to WT mice after AOM/DSS treatment yet these mice displayed more severe intestinal inflammation than WT mice.
While one study utilizing female progestin receptor knockout (PRKO) mice did report anxiolytic-like effects of P [18], another study reported that male PRKO mice displayed more anxiety-like behavior in the elevated plus maze.
Fmr1 knockout mice displayed more anxiety-related behaviors during social interaction (grooming, rearing, and digging) than wild-type mice, which was ameliorated by inhibition of GSK3 with chronic lithium treatment.
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