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In addition, the mice display major cognitive deficits affecting visuo-spatial learning abilities [31].
Moreover, the mice display major changes in membrane biophysical properties.
The present findings clearly demonstrate that Tc1 mice display major changes in novelty-driven spontaneous activity characterized by spontaneous hyperlocomotion, abnormal exploratory behaviour and impaired habituation to the test environment.
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We found that IL-22−/- mice displayed major defects in the skin's dermal compartment after full-thickness wounding.
Interestingly, PlGF-deficient mice do not display major vascular abnormalities, unlike mice lacking VEGF, suggesting that this molecule is not essential during physiological angiogenesis [ 40].
Consistently, leptin-deficient mice are not only obese, but display major hormonal disturbances, including hypercorticosteronemia, diabetes, and infertility.
In fact, while XO mice are fertile and do not display major physiological abnormalities, TS females present ovarian dysgenesis and other anatomical and physiological abnormalities [ 25].
To date these mice are viable and fertile and do not display major behavioral phenotypes on home cage behavior.
Uchl1 nmice9 (UCHL1−/−) mice, which lack all UCHL1 function (Walters et al. 2008), display major motor function defects without significant sensory ataxia.
They report that homozygous Rab18 mice display many of the major ocular and neurological abnormalities that are associated with Warburg Micro syndrome, including congenital nuclear cataracts, atonic (constricted) pupils and progressive limb weakness.
However, L. major infected WSX-1-/ mice display acute defects in IFN-γ production and lesion resolution (Fig. 3) [ 37, 43, 44].
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