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Conversely, DBA/2J mice display low rates of ethanol consumption.
129P3/J mice display low morphine tolerance and dependence in contrast to high sensitivity to precipitated withdrawal observed in SWR/J and C57BL/6J strains.
These mice display low but continuous STAT3 activity in all tissues, which led to accelerated oncogene-mediated breast tumourigenesis and increased metastasis, altered energy metabolism and predisposition to tumour transformation (Barbieri et al, 2010; Demaria et al, 2010, 2012).
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As a result, HDC−/− mice displayed low nuclear levels of NF-κB p65 in CLP-induced sepsis.
Freshly purified blood neutrophils from STAT5−/− and control mice displayed low and similar levels of apoptosis (Figure 2A).
Microcomputed tomography (micro-CT) and bone histomorphometry analyses showed that Cthrc1-null mice displayed low bone mass as a result of decreased osteoblastic bone formation, whereas Cthrc1 transgenic mice displayed high bone mass by increase in osteoblastic bone formation.
The heart and kidney from BM-transplanted eNOS−/− mice displayed low quantities of donor-derived EGFP.
In contrast to Li–Fraumeni patients with the corresponding R175H or R273H mutations, these mice displayed low frequency of mammary carcinomas (26, 27), similar to TP53 knockout mice (Table 1) (29, 29).
Of note, the majority of the remaining lung CD11c+ cells in inhibitor-treated mice displayed low side-scatter profiles (Fig 4E right), suggesting that IMCs with increased intracellular granularity were mostly depleted from the lung by the inhibitor.
Indeed, C57Bl recipient mice depleted of NK cells through repeatedly administration of NK1.1-specific antibodies (Fig. 7) maintained US11-hMSCs implants at levels similar to those in NOD/SCID mice, which naturally display low NK cell activity (Fig. 5B, lower panel).
In good agreement with this, Cby−/− mice display a low abundance of motile cilia in large airways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com