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During proestrus and estrus rats and mice display less anxiety-like behavior than during diestrus.
BACH1 has been implicated in cardiac hypertrophy as knock-out mice display less hypertrophy following pressure-overload [ 35].
TWEAK knockout mice display less atrophy than wild-type mice during denervation, as well as reduced NFκB activation and MuRF1 expression (Table 1).
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Compared with WT mice, PEPCK mice displayed less sleep, particularly during the late light phase, and this was accompanied by decreases in slow wave sleep (SWS) and rapid eye movement (REM) sleep.
EpCAM+ TECs from Adam17/Foxn1 mice displayed less than 2% the Adam17 levels of littermate controls (Figure 1B).
These results are similar to previous reports that Fmr1 knockout mice displayed less social approach behavior with a novel mouse than wild-type mice [13], [17].
While untreated mice and BU-pretreated mice displayed less than 0.2% chimerism, radiation-treated mice displayed gradually increasing levels of chimerism up to 80% in lethally irradiated (900 RAD) mice (Fig. 2B).
As further demonstrations of the role of GluR5 in anxiety, we found that wild-type mice displayed less anxious behavior when receiving ATPA whereas they showed more anxiety by local GluR5 antagonism in the BLA.
In a previous study, CaMKIV KO mice showed impaired memory in a contextual fear conditioning test; CaMKIV KO mice displayed less freezing behavior than control mice in both the context test and cued tests conducted 1 day and 7 days after training [33].
Prkg1SMr mice displayed less REMS in the first half of the light period, a deficit that was entirely compensated in the second half and, conversely, showed more REMS in the first half of the dark period, a surplus that was again lost in the second half.
Consistent with the nuclear localization of phosphorylated YAP, MST2−/− mice displayed less p73 binding phosphorylated YAP than WT mice.
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