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These model mice display large amyloid deposition burden at a very early age (2 month), and exhibit intraneuronal Aβ42, neurodegeneration and neuronal loss [35].
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These mice display larger infarcts and worse cardiac injury post I-R [ 37].
Sirt1−/− mice display larger infarct volumes than their wild-type counterparts after being subjected to brain ischemia, thus suggesting the remarkable neuroprotective action of endogenous SIRT1 in stroke.
Instead, the PCP-treated mice displayed large and significant acquisition deficits during the place condition relative to the control mice that were greater than those observed during the P75 place trials [Group effect: [F (1,56) = 16.77, p<0.0005; Group by Blocks interaction: F (4,224) = 4.41, p = 0.003] (Fig. 4H).
However, these two estrogen-lymphoma mice displayed large variations in expression of other miRNAs such as miR-127, miR-327, and miR-31 (Additional file 1: Figure S2).
BID (Fig. 5A) and OD (Fig. 5C) HEC-treated mice displayed large wound beds with necrotic debris evident, with little indication of reepithelialization.
However, 10 out of 18 (55.6%) VHL+/− and 4 out of 4 (100%) EAF2−/−VHL+/− mice displayed large discrete lesions visible both on the surface of the liver and within the liver parenchyma (Fig. 2a).
However, by 3 DPI, the lungs of young mice began to display large foci of necrotic infiltrates and tissue destruction (Fig. 2B).
RIP1-Tag2 HRG−/− mice display significantly larger tumor volume compared to their RIP1-Tag2 HRG+/+ littermates, supporting a role for HRG as an endogenous regulator of tumor growth.
DCT:: lacZ fascin 1-/ mice generally displayed large white patches on the abdomen (supplementary material Fig. S1C).
The compounds display large thermal hysteresis.
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