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TRAMP mice display high grade prostatic intraepithelial neoplasia or well-differentiated prostate cancer by 10-12 weeks of age.
At 9 months of age, APPswe/PS1dE9 transgenic mice display high levels of amyloid β-peptide and numerous amyloid β-peptide deposits [16].
Hence, GR knockout mice display high basal CBG levels that are not suppressed by Dexamethasone.
Surprisingly, CD38-KO mice display high level of NADase activity (~50% of the WT activity) at ZT23.
However, the double mutant Pten+/-: Nxk3.1+/- mice display high grade PIN/early carcinoma lesions at a high frequency [ 24, 25].
Ms5Yah mice display high postnatal lethality, with a few surviving individuals showing growth retardation, motor coordination deficits, and spatial learning and memory impairments.
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While MnSOD-/ mice are neonatal lethal the MnSOD+/- mice display higher oxidative damage and incidence of tumor formation [ 31, 32].
Liu et al., [ 32] showed that caspase-1 KO mice display higher arthritis scores at day 14 postinfection.
These mice display higher bone mass in both cortical and trabecular bone, greater trabecular and cortical thickness, and normal bone strength [ 7, 8].
The green muscle fibers derived from myoblasts of GFP transgenic mice displayed a wider distribution and were more uniform in morphology one month post-transplantation, indicating that myoblasts from GFP-transgenic mice display higher differentiation potential.
In addition the early postnatal hearts of the transgenic mice display higher levels of reduced GSH and a higher ratio of GSH/GS-SG than wild-type littermate controls.
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