Relative to wild-type controls, Nrxn1α homozygous KO mice display heightened aggression toward, and less social investigation of, juvenile mice, while also expressing anxiety-like behavior in a light/dark box (Grayton, Missler, Collier, & Fernandes, 2013).
Fmr1 knockout mice displayed heightened anxiety-related behaviors during social interaction, as a higher percentage of Fmr1 knockout mice than wild-type littermates displayed greater grooming times than the group median in both the sociability period and the social preference period, and spent more time rearing and digging.
Upon intranasal infection with VSV, the Peli1-deficient mice displayed heightened in vivo IFN-I responses in the CNS, coupled with reduced brain viral titer and increased survival rate.
However, when they are forced into this novel compartment the animals display heightened anxiety levels, as measured by elevated corticosterone [61].
Surprisingly, ERα-depleted tumorspheres display heightened sensitivity to 4-OHT and their sphere-forming capacity is diminished after the drug is removed.
Accordingly, they often display heightened or prolonged physiological responses to acute emotional stressors (2,4,23,24).
In the absence of Sae2, cells display heightened DNA damage signalling as measured by Rad53 hyperphosphorylation (Clerici et al, 2006).
When resting T cells become activated and proliferate under the influence of growth cytokines, they display heightened sensitivity to apoptosis [ 3, 5, 6].
Though we expected more vulnerable animals to display heightened antipredator responses, individuals in better body condition suppressed foraging more than individuals in poorer body condition.
Studies from the 1990s demonstrated that B cells isolated from a subset of hypertensive patients display heightened activity of NHEs [ 81, 82].
In keeping with this trend, AKAP150ΔPIX mice also displayed heightened insulin sensitivity as blood glucose more rapidly declined following exogenous insulin injection in AKAP150ΔPIX mice than in WT.
