When crossed into an iNOS-null background these mice displayed extensive tau pathology associated with regions of dense microvascular amyloid deposition.
These mice displayed extensive damage and persistent immune infiltration of inflamed tissues, and, in the case of generalized inflammation, overwhelming mortality.
We found that virgin SirT1ko/ko mice displayed impeded ductal morphogenesis up to 9 months of age, while age-matched virgin wild-type mice displayed extensive ductal elongation and branching.
Untreated mice displayed extensive callosal demyelination (Fig. 2a, d), whereas mice treated with 25 mg/kg showed mainly intact callosal myelin with only focal signs of demyelination (Fig. 2c, f).
STAT-1 mice failed to display extensive thrombocytopenia that is characteristic of NW disease but did display clinical and histopathological similarities, including splenic necrosis.
Naïve HIS mice display an extensive human IgM-expressing B cell repertoire.
They showed that Vdr knockout female mice display more extensive ductal elongation and branching when compared with their wild-type counterparts.
A possible functional relation between neurofascin and PrPC is particularly intriguing in view of the lethal phenotype of transgenic mice expressing PrP deletion mutants, which display extensive central and peripheral myelin degeneration [19].
For mouse, it has been shown that X and Y chromosomes display extensive side-by-side pairing early in meiotic prophase, which decreases in length as meiotic prophase progresses [56].
