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Herein, we report that Apoai and Apoe mice display enhanced recruitment of neutrophils to the airspace in response to both inhaled lipopolysaccharide and direct airway inoculation with CXCL1.
However, S100A8/A9 knockout mice display enhanced renal damage and fibrosis that correlates with increased expression of M2 macrophage markers raising some controversy about the role of S100A8/A9 in TLR mediated fibrosis [190].
Such a phenomenon could explain why STAT5−/− mice display enhanced granulopoiesis and develop neutrophilia.
In this behavioral model, delta agonists show anti-allodynic and anti-hyperalgesic properties [17] [19] and delta receptor knockout mice display enhanced pain [28].
We presently report that synaptic excitatory currents in mice bearing a loss-of-function mutation in the DAP12 gene (DAP12KI mice) display enhanced relative contribution of AMPA.
Nevertheless, NOS2 mice display enhanced morbidity and mortality after administration of endotoxin or TNF.
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Finally, myriocin-treated DIO mice displayed enhanced oxygen consumption rates (3,041 ± 124 vs. 2,407 ± 124 ml/kg/h) versus their control counterparts.
Accordingly, the colon of TLE-fed, DSS-exposed NF-κBEGFP mice displayed enhanced EGFP expression compared to control diet-fed mice (Fig. 4C).
In an elevated plus maze test, DGKβ KO mice displayed enhanced open arm selectivity, which also indicates lowered anxiety of DGKβ KO mice.
DG-Eno2-ΔGR/EGFP bigenic mice displayed enhanced stress-related behaviors and in particular higher anxiety- and depression-related behaviors in response to unavoidable aversive situations.
Conversely, IL-1Ra-deficient mice displayed enhanced atherosclerosis.
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