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In addition, ARTE10 mice display early loss of synaptic markers and age-related cognitive deficits.
CTLA-4 knockout mice display early lethality, unlike PD-1 knockouts, which demonstrate late-onset and organ-specific autoimmunity.
This finding is consistent with a previous experimental study showing that OVX mice display early hepatic inflammation [ 13].
To determine if Mcoln1 −/− mice display early locomotor and behavioral deficits, spontaneous activity of one- and two-month-old naïve Mcoln1 −/− mice and wild-type littermates was tested in the open field arena.
Whereas the overexpression of ALKBH4 only marginally alters the global gene expression pattern in the HEK293 cell line, homozygous Alkbh4 mutant mice display early embryonic lethality, which indicates that Alkbh4 plays an essential role in early developmental processes.
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We found that adult heterozygous mice have reduced seizure thresholds, and homozygous mice display early-life spontaneous seizures associated with neuronal loss in the hippocampus.
These mice displayed early synaptic dysfunction before plaque or tangle deposition was evident, together with early intraneuronal Aβ immunoreactivity preceding plaque deposition.
Six hours following a single SQLLNAKYL i.v. injection 7 days p.i., the mice displayed early signs of ECM and seven out of eight died of convulsions after folic acid challenge (Fig 8).
Female Sod1 D83G/D83G mice displayed earlier deficits in accelerating rotarod compared with males (23 weeks versus 67 weeks) (Fig. 3D; Supplementary Material, Fig. S3D).
Here, we show that Ret and Gfrα2 null mice display comparable early central projection deficits, but Gfrα2 null RA mechanoreceptors recover later.
These mice display an early-onset loss of peripheral nerve axons and abnormal morphology of the neuromuscular junction.
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