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Two different lines of mice devoid of cellular prion protein, Zrch I Prnp0/0 and Ngsk Prnp0/0, were used.
Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
Both Ccbe1 null mice and mice devoid of the Ccbe1 C-terminal collagen-like domain showed a complete lack of lymphatic structures, whereas mice devoid of the Ccbe1 N-terminal EGF-like domain showed some clusters of lymphatic endothelial cells (LECs), which were unable to form contiguous structures, suggesting that the CCBE1 N-terminal domain is involved in the organization and migration of LECs15.
Sure enough, the lymph nodes of mice devoid of mast cells remained small after infection.
Notably, mice devoid of Dpl are sterile.
Studies have been conducted on several strains of mice devoid of PrPC, but these animal models have not been able to clarify PrPC actual functions.
Experiments were performed on mice devoid of the capsaicin receptor (TRPV1 [27]; strain B6.129X1-Trpv1) purchased from The Jackson Laboratory (Bar Harbor, Maine).
Defects and polymorphisms in the POLI are associated with an increased risk of lung cancer [25]; [26] and 129/J mice, devoid of Pol ι, are prone to an elevated occurrence of UV-induced skin tumors [27]; [28].
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10 In the obese ob/ob mouse devoid of leptin production, ObR mRNA is increased in these hypothalamic regions, piriform and olfactory cortices, and the medial habenular nucleus in comparison with lean mice.
In the Eed−/− mouse, devoid of H3K27me3, the Xi remains silenced at the blastocyst stage in both ICM and trophoectoderm (Kalantry and Magnuson 2006; Kalantry et al. 2006; Wang et al. 2001).
Target to background ratios were not calculated for Cre recombinase negative littermate control mice or hyperplastic Kras mice, because these mice were devoid of adenomas.
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