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Wire myograph-mounted femoral arteries from 5-day CLP mice developed lower tension under stimulation with U46619 (0.1 μM) compared to those from sham mice.
Wire myograph-mounted femoral arteries from 5-day CLP mice developed lower tension under stimulation with a depolarising high-K+ HT solution compared to those from sham mice.
Wire myograph-mounted femoral arteries from 5-day CLP mice developed lower tension under stimulation with PDBu (5 μM) compared to those from sham mice.
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On the other hand, both LDL receptor-deficient (LDLR-/) and particularly apolipoprotein E-deficient (ApoE-/) mice display marked atherosclerosis [ 28, 29] but ApoE-/ mice develop lower diet-induced obesity, less profound insulin resistance and adipose tissue inflammation when fed a high-fat diet [ 30- 32].
LY411,575-treated mice developed significantly lower levels of blood parasitemia when compared to control animals, very evident during the days before development of severe symptoms (Fig. 4B).
MIF KO mice developed consistently lower stage tumors with less associated angiogenesis in a BBN model of bladder cancer.
In contrast to the phenotype seen in IFNAR1-/ mice [ 33], pristane-treated IFNAR2-/ mice developed significantly lower levels of the pathogenic isotype IgG2a as compared with pristane-treated WT mice.
Together with results obtained from a murine model of asthma [14], the studies provide consistent evidences that gal3−/− mice develop a lower Th2 response but a higher Th1 response compared with gal3+/+ mice.
Pristane-treated IFNAR2-/ mice develop significantly lower titers of IgG autoantibodies directed against these two targets.
Further, MCP-1 knockout mice develop a lower degree of oxidative stress and accumulation of inflammatory cell infiltrate than their corresponding wild-type animals when receiving a single CCl4 dose [ 34].
The slower growth of a clone of pretumoral cells could partially explain why mFwe-deficient mice develop a lower number of papillomas when treated with DMBA/TPA (Fig. 4C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com