Stenotic kidneys of db/db mice developed progressive interstitial fibrosis, tubular atrophy, and interstitial inflammation.
Despite the lack of requirement for NOX2 for the development of pressure overload hypertrophy, it was found that NOX2 knockout mice developed less interstitial fibrosis and contractile dysfunction than wild-type littermates [ 41] indicating a dissociation between hypertrophy per se and fibrosis or contractile dysfunction.
It was found that BALB/c mice developed severe interstitial pneumonitis 10 days postinfection.
In addition to the glomerular lesions, the contralateral kidney of db RAS mice developed progressive interstitial fibrosis significantly greater than that of db sham mice, WT RAS, or WT sham mice at the same time point.
Db/db mice with Angiotensin II-induced hypertension developed interstitial lesions and albuminuria but not mesangial matrix expansion, while nephrectomized db/db mice exhibited modest mesangial expansion and interstitial fibrosis, but not significant albuminuria.
The recently developed interstitial high-entropy alloys (iHEAs) exhibit an enhanced combination of strength and ductility.
Two patients developed interstitial pneumonitis.
Two patients developed interstitial pneumonitis, which resolved with corticosteroid and discontinuation of temsirolimus.
Grade 4 pulmonary toxicity occurred in one patient who developed interstitial pneumonia and died.
One patient developed interstitial lung disease (ILD) (Ando et al, 2006).
