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For example, after subcutaneous injection of the chemical carcinogen methylcholanthrene, Rag2−/− background mice developed higher frequency of sarcomas compared to the strain-matched controls [24].
Intact female mice developed higher levels of parasitaemia than male mice between days 5 and 7 after infection.
However, even the intact group of infected female mice developed higher levels of NO compared with their intact male counterparts.
These mice developed higher blood pressure than wild-type mice, which was related to higher levels of circulating endothelin-1 and enhanced production of reactive oxygen species.
a QD mice developed higher mean maximum disease scores than mice from the B10.Q, DBA/1, B10.P, and B10.RIII strains (P < 0.05).
In most compartment using most of the different vaccine regimens, younger mice developed higher frequencies and numbers of NP-specific CD8+ T cells compared to aged mice.
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But as they were subjected to stress — pregnancy for the females, aging for the males — the mice developed high blood sugar, decreased insulin secretion and other signs of Type 2 diabetes.
We herein showed that rats and mice developed high titers of anti-Kv1.3 antibodies and appeared no abnormal manifestations after the PADRE-Kv1.3 vaccine treatment.
Thus, intravenously immunized mice developed high poxvirus specific IgG titers with neutralizing capacity.
All rEBNA-1 injected mice developed high titers of antibody to EBNA-1 and dsDNA.
Seven of eight (88%) of tumor bearing AOM/Il10−/− mice developed high-grade or invasive carcinoma while none of the 3 tumors observed in WT mice showed evidence of advanced histological stage (Fig. 3A).
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