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PPAR α null mice develop more hypertrophy, production of more reactive oxygen species as well as an exaggerated production of extracellular matrix components [ 35, 36].
Supplementary Figure 6 Pik3cdE1020K/+ mice develop IgM autoantibodies.
Aged Pten-ΔTreg mice develop non-malignant TH1 inflammation.
Concurrently, mice develop delayed deficits in LTP and cognition.
Bad-deficient mice develop diffuse large B cell lymphoma.
Both NOS1-/ and NOS3-/ mice develop age-related hypertrophy, although only NOS3-/ mice are hypertensive.
This sex difference may be strain/species specific, as both male and female 129SvEv mice develop learned helplessness [ 63].
Although there are clear species differences between humans and mice, laboratory-bred female mice developed cancer when doxorubicin [ 9] or fluorouracil (our unpublished findings) was injected intraductally, with a latency of nearly a year.
The mice developed F.F.I.
The normal mice developed osteoarthritis as expected.
There was no significant difference between Krt76+/+ and Krt76+/− mice; however, Krt76−/− mice developed OSCC earlier.
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