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Tricellulin-deficient mice develop rapidly progressing hearing loss accompanied by loss of mechanosensory cochlear hair cells (Nayak et al., 2013).
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Untreated mice developed rapidly progressive disease and were sacrificed when moribund (∼day 19).
Instead, Nrf2 KO mice developed rapidly growing, aggressive mammary carcinomas that were larger than the WT mammary carcinomas.
After an initial symptom-free period of ∼10 days, K14-lnl/lnl mice developed rapidly-progressing neurological disease, leading to continuous seizures and paralysis at 2 weeks of age, which was associated with neuronal loss and microglia activation and proliferation.
By the end of the summer, the interns had come up with the mouse lemur, which fits all the necessary criteria: Like mice, these animals are small (about twice the size of a mouse), develop quickly, reproduce rapidly, produce many offspring, and are inexpensive and easy to maintain and manage.
High Irga6 expression patches are not present in newborn mice but develop rapidly in both the kidney and liver between 1 week and 3 weeks after birth.
Seventy percent of mutant mice develop a rapidly progressive (RP) phenotype and most of them die during the first two months of life.
At 4 6 weeks of age, the mice develop a rapidly progressive dilated cardiomyopathy (DCM), with death usually around 8 weeks [15].
In female AKR/J mice lymphoma developed rapidly, usually associated with lymphadenopathy.
Destructive changes develop rapidly.
These mice develop AAH lesions rapidly and with high penetrance, and a subset of these lesions progress to adenocarcinomas.
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