Similar to the findings of the whole-body KO, the cardiomyocyte-specific KO mice developed prominent signs of cardiomyopathy, excessive cardiac fibrosis, and elevated expression of the hypertrophy marker Acta1 by age of 24 weeks.
The role of the Aβ42/Aβ40 ratio is an important determinant of the distribution of Aβ in vessels or in parenchyma: the APPDutch mice (E693Q APP751) develop prominent amyloid angiopathy, associated with an increased level of Aβ40.
P301S mice develop not only tau aggregation but also prominent neurodegeneration.
Interestingly, important loss of B cells and development of altered germinal centers (GC) were detected in the spleen of mice infected with strain CbaAr-4005, whereas mice infected with SLEV CorAn-9275 developrominentnent GC with conserved follicular architecture, and neutralizing antibodies.
Homozygous APP24 mice develop the first plaques between 3 and 4 months of age without a prominent gender difference.
We report a Japanese mother and daughter with FAF who developed prominent nephropathy.
K/BxAg7 mice developed a destructive arthropathy followed by prominent aortic atherosclerosis.
The AP of control and Bmpr1a-CKO mutant mice developed normally with respect to gross morphology and hematoxylin and eosin sections at stage P14, when prominent epithelial differentiation was observed.
Demyelination was a prominent and consistent finding, with 100% of MHV-infected mice and 85% of EAE mice developing demyelination.
