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The female NOD mice develop overt diabetes at the age of 12 wks and the incidence reaches 80% by 25 wks of age.
Most NOD mice will develop severe insulitis by 10 weeks of age, and, in our experiments, a small percentage (<10%) of mice develop overt hyperglycemia by 12 weeks of age [1].
We have established that sarcolemmal-associated β-catenin is a substrate for Ozz-E3 and that ozz−/− mice develop overt sarcomeric defects, which we have attributed in part to the impaired turnover of β-catenin at the membrane of differentiating myofibers [12].
In particular, females with RTT develop symptoms as young children whereas heterozygous Mecp2-KO mice develop overt phenotypes late on in adulthood and they are generally much milder.
During the acute phase of infection, mice develop overt signs of infection (hunched posture, reduced movement, loss of body weight, piloerection).
Similar to the natural history and therapeutic response of the human disease, Dlx-CKO mice develop overt, dystonic-like twisting movements during juvenile CNS maturation that are reduced significantly with antimuscarinic drugs.
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The dose of bacteria was high enough to be detected in the intestine, but not so high that the mice developed overt illness.
The polycythemia induced by JAK2 V617F was maximal at 3 to 4 months post-transplantation, but tended to decrease with time in both strains, with hematocrit and reticulocyte counts returning to nearly normal ranges by 7 to 8 months after transplantation (Figure 5A), and some mice developing overt anemia.
None of the mice developed overt diabetes.
Fasting blood glucose and body weight in db mice were significantly elevated relative to controls, and increased over the duration of the protocol as the db mice developed overt diabetes.
In contrast, only 3 of 17 NS mice developed overt leukemia within the same time frame after reinjection with CD22-RTM transfected xenograft cells 2-Tailed Fisherr's exact, P < 0.0001).
More suggestions(15)
mice have overt
mice develop high
mice develop glaucoma-like
mice develop local
mice develop severe
mice develop pituitary
mice develop spontaneous
mice develop renal
mice develop progressive
mice develop hepatic
mice develop significant
mice develop thymic
mice develop systemic
mice display overt
mice develop α-synuclein-dependent
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