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(B ) The Eμ-myc/17-92Mut92 and Eμ-myc/17-92Δ92 mice developed high grade B-lymphomas that were frequently disseminated into the liver.

A 24-week time point was chosen as adequate time for early-stage disease progression in our heterozygote mice since previous studies indicated that C3(1)Tag male mice develop high-grade prostatic intraepithelial lesion (HGPIN) at 20 weeks (14).

When these oncogenic mutations are activated in KP mice by injection of adenovirus expressing Cre recombinase (Ad-Cre), the KP mice develop high-grade primary STS at the site of injection in 2-4 months (Fig. 1A,B).

Seven of eight (88%) of tumor bearing AOM/Il10−/− mice developed high-grade or invasive carcinoma while none of the 3 tumors observed in WT mice showed evidence of advanced histological stage (Fig. 3A).

In addition, low-grade dysplasia was evident at 6 weeks after initiation of disease, and by 12 weeks, all the mice developed high-grade dysplasias and adenomas (two to three tumors per mouse, 100% penetrance, Figure 4A, panels d f).

In our model the mice develop high levels of Hgb.

Both Wap-p53R172H; Rb1+/+ and Wap-p53R172H; Rb1ΔL/ΔL females developed high grade mammary adenocarcinomas, characterized by high cytological variability.

These women have an increased risk for developing high grade dysplasia and cancer (CIN2+) compared to women with normal cytology.

Two out of 8 (25%) developed high grade leiomyosarcomas.

On February 2 , 2002Randhir developed high grade fever with chills and rigors.

Over the course of a year these mice went on to develop high-grade PIN lesions as well as invasive carcinoma.

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