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Epgn is expressed in undifferentiated sebocytes, and Epgn transgenic mice develop enlarged SGs due to expansion of basal, undifferentiated cells in the gland in response to Epgn overexpression (Dahlhoff et al, 2010).
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Strikingly, all Cicf/fVav1-Cre mice developed enlarged secondary lymphoid organs, including spleens (Fig. 1a), mainly due to proliferation of B220+ B cells (Fig. 1b).
BHDflox/flox/Ksp-Cre mice developed enlarged kidneys characterized by polycystic kidneys, hyperplasia, and cystic renal cell carcinoma.
These mice developed enlarged spleens, high monocyte count, and preleukemia (myeloproliferative disease) after one year.
In the basal forebrain of Ts65Dn mice, neurons develop enlarged endosomes at two months.
In 1991, a mouse strain was serendipitously discovered for its resemblance to patients with the disease Systemic Lupus Erythematosus, that is, the mice showed a tendency to develop enlarged lymph nodes and spleens along with autoimmune diseases such as immune complex glomerulonephritis.
Furthermore, mice aquaglyceroporin AQP7 knockouts accumulate glycerol and TAGs, and develop enlarged adipocytes and obesity with age.
An amazing study by Chenn and Walsh [ 13] showed that transgenic mice expressing a stabilized form of β-catenin in neural precursor cells develop enlarged cerebral cortices with complex gyral patterns resembling those of primates.
Mice implanted with E μ- myc tumours typically develop enlarged lymph nodes, spleens and thymus by 2 4 weeks post implantation.
At puberty, over 80 percent of them develop enlarged breasts, and approximately half menstruate.
Infected persons will develop enlarged lymph nodes resulting in open sores at advanced stages.
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