A chimeric DR4 homozygous transgenic mouse line was reported to spontaneously develop diverse hematological malignancies at a high frequency.
A chimeric HLA-DR4-H2-E (DR4) homozygous transgenic mouse line spontaneously develops diverse hematological malignancies with high frequency (70%).
Supplementary Figure 6 Pik3cdE1020K/+ mice develop IgM autoantibodies.
Aged Pten-ΔTreg mice develop non-malignant TH1 inflammation.
Concurrently, mice develop delayed deficits in LTP and cognition.
Bad-deficient mice develop diffuse large B cell lymphoma.
Both NOS1-/ and NOS3-/ mice develop age-related hypertrophy, although only NOS3-/ mice are hypertensive.
FVB-MetM1248T/L1193V and FVB-MetY1228C mice developed similar mammary tumors with diverse features such as squamous metaplasia and solid and tubular patterns.
We have previously generated BOK-deficient mice; like BAX or BAK singly deficient animals, Bok −/− mice developed normally and were healthy; moreover, their leukocytes were normally sensitive to diverse cytotoxic stimuli.
The mice developed F.F.I.
The normal mice developed osteoarthritis as expected.
