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Aged apoE−/− mice develop advanced atherosclerotic lesions similar to those in human arteries.
KPC mice develop advanced PDAC from 2 to 3 months and have a shortened median survival of approximately 5 months.
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Both groups of mice developed advanced atherosclerotic lesions that contained cholesterol clefts and necrotic areas.
With this method mice developed advanced clinical signs between 307 336 dpi.
The apoE-/-/LDL-/ double knockout mouse develops advanced atherosclerotic lesions with high similarity to human disease [ 13].
Animals were euthanized after 50 days on the diet, an age at which Ldlr−/− mice do not develop advanced atherosclerotic lesions (Ma et al., 2012) or monocytosis (Murphy et al., 2011).
Consistently, hyperlipidemic rabbits exposed to PM10 (particulate matter ≤ 10 μm in aerodynamic diameter) or ApoE−/− mice exposed to PM2.5 (≤ 2.5 μm ) develop advanced coronary and/or aortic atherosclerosis (Chen and Nadziejko 2005; Sun et al. 2005).
Apolipoprotein E-deficient (apoE-/) C57BL/6 (B6) mice are established models of atherosclerosis that develop advanced atherosclerotic lesions when kept on a high fat diet [ 14].
Bentley is working with energy companies to develop advanced biofuels.
Graduate studies are expected to develop advanced cognitive skills.
However, not all H. pylori positive cases develop advanced disease.
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