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Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation.
Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements.
Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment.
The presence of purulent pleural effusions and increased pleural lavage neutrophilia in PAI-1−/− mice compared to WT mice demonstrates that local inflammation is worsened by PAI-1 deficiency.
Representative morphology of lung sections from WT, βENaC-Tg, MMP12−/−, and βENaC-Tg/MMP12−/− mice demonstrates that increased MMP12 activity on BAL macrophages also contributes to structural lung damage (right lower panels).
In summary, the cross of βENaC-Tg mice with NE−/− mice demonstrates that NE is implicated in the in vivo pathogenesis of several key features of CF-like lung disease including the modulation of neutrophilic airway inflammation, induction of goblet cell metaplasia and mucin hypersecretion, and structural lung damage [15].
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p65EHT mice developed papillomas similarly to p65FL mice demonstrating that heterozygous loss of p65 in the epidermis was not sufficient to prevent tumour development (Fig 1D and E).
Moreover, ufd2a knockout studies in mice demonstrated that the protein is essential for myocardial development31.
Finally, studies in Nrf2−/− mice demonstrated that dimethyl fumarate affects immune cell functions in a Nrf2-independent manner14.
Dolichos biflorus lectin staining in appropriate mice demonstrated that the cells move in straight vertical columns (Winton et al. 1988).
Real-time imaging of HCV internal ribosome entry site (IRES) firefly luciferase reporter mRNA translation in living mice demonstrated that the HCV IRES was functional in mouse liver.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com