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Moreover, quantitative real-time PCR results obtained during a 3-week time-course study of virus replication in spleens, livers and salivary glands of infected mice demonstrated sensitive, accurate and reproducible detection and measurement of infectious MCMV.
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A sensitive neurovirulence test in 2 3 day old neonatal mice demonstrated that RV-RabG candidates were completely avirulent indicative of high safety.
Additional studies in congenic BALB/c, nude, and beige/Scid mice demonstrated dose-dependent hepatotoxicity and indicated that beige/Scid was the most sensitive strain.
LNCaP cells are also sensitive to IL-6 as an interesting study demonstrated that IL-6 exposed tumors injected into nude mice demonstrated an abrogation of proteins involved in cell cycle control.
All mice demonstrated full visual capability.
Three mice demonstrated subarachnoidal hemorrhages.
All mice demonstrated hyperactivity during housing.
Tumor TACs were obtained after i.v. injection of [11C]erlotinib into NSCLC tumor-bearing mice, demonstrating increased radioactivity uptake in erlotinib-sensitive tumors (HCC827 and NCI-H3255) compared to insensitive (QG56) or resistant NCI-H19755) ones.
The consistent outcome of the immunostaining, in situ hybridization, RT-qPCR experiment, analyses of Runx3-GFP and R26-reporter (LacZ and tdTomato) mice and our failure to reproduce the results of Li et al (Li et al, 2002) using the Kyoto-Runx3LacZ/LacZ mice demonstrate unequivocally that the expression of Runx3 in GIT is below the detection limit of these highly sensitive assays.
Here we report the transmission of the FSE case 1 (the mother of case 2) into the Tg(OvPrP4) mouse model that has been demonstrated as sensitive to and efficient at detecting the BSE strain of agent [2], [15], [16].
In addition, studies in mice have demonstrated that the animals are more sensitive to spontaneous tumor development when beclin-1 is monoallelically disrupted.
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