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The seminiferous tubules in control mice demonstrated regular features.
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All animals in SHAM group demonstrated regular 4 to 5 days of estrous cycle.
We also demonstrated regular hexagonal ordering of cones using the Voronoi method.
Saline-treated PAI-1−/− mice demonstrated significantly less IL-13 than similarly treated WT mice (p < 0.05).
Further, S. pneumoniae infected-PAI-1−/− mice demonstrated significantly higher plasmin activity than infected WT mice (p = 0.04).
S. pneumoniae-infected PAI-1−/− mice demonstrated significantly higher plasmin activity than identically treated WT mice (p = 0.04).
All mice demonstrated full visual capability.
Three mice demonstrated subarachnoidal hemorrhages.
GRHL3 -/- mice demonstrated defects in cell migration.
All mice demonstrated hyperactivity during housing.
Consistent with previously published studies, which have demonstrated that mice cease regular estrus cycling by 8 14 months of age [ 18],[ 19], in the present study and our earlier work, our cohorts of aged female mice enter reproductive senescence by 14 months of age [ 15].
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