Sentence examples for mice demonstrated progressive from inspiring English sources

In the grip strength test, the knock-in mice demonstrated progressive muscle weakness in forelimbs.

Similarly, VMAT2-deficient mice demonstrated progressive non-motor symptoms prior to the onset of motor deficits (Taylor et al. 2009).

MRL/lpr mice demonstrated progressive development of pneumonitis and sialadenitis, which became noticeable at 10 to 12 weeks of age.

Tyr423His Myoc mice demonstrate progressive degenerative changes in the peripheral RGC layer and optic nerve, with normal organization of aqueous drainage structures [ 101].

Mice demonstrate progressive muscle weakness starting approximately at the age of 6 months.

However, a recent conditional parkin knockout mouse model demonstrated progressive loss of dopamine neurons in a PARIS-dependent pathway [ 128].

With age, however, ATXN2 Q127-mutant mice demonstrated a progressive decline in motor performance.

Kobayashi et al [ 30] showed that Dicer, an enzyme involved in the miRNA pathway, was essential for chondrocyte function in mice; the growth plates from Dicer-null mice demonstrated a progressive reduction in the proliferating pool of chondrocytes, leading to severe skeletal growth defects and premature death of the mice.

This hypothesis is consistent with the results obtained in WFS animal models by Ishihara et al. [ 12] who demonstrated progressive loss of β-cells in mutant mice while the α-cells were completely preserved.

On the other hand, transgenic mice over-expressing the most common human IBMPFD mutation, R155H, under the regulation of a muscle creatine kinase promoter demonstrated progressive muscle weakness in a dose-dependent manner starting at 6 months of age.

Further MRI studies demonstrated progressive reduction of the haemorrhagic component over time (b, c).