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The mice demonstrated left ventricular systolic dysfunction and heart dilatation, related to a significant increase in the number of apoptotic cardiomyocytes and fibrosis.
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Selective deletion of endothelial ETB receptors in mice (demonstrated by autoradiography to leave unaltered ETB receptors expressed by other cell types) impaired, as expected, the clearance of an i.v. bolus of labelled ET-1 compared with controls (Bagnall et al., 2006; Kelland et al., 2010).
Saline-treated PAI-1−/− mice demonstrated significantly less IL-13 than similarly treated WT mice (p < 0.05).
Further, S. pneumoniae infected-PAI-1−/− mice demonstrated significantly higher plasmin activity than infected WT mice (p = 0.04).
S. pneumoniae-infected PAI-1−/− mice demonstrated significantly higher plasmin activity than identically treated WT mice (p = 0.04).
All mice demonstrated full visual capability.
Three mice demonstrated subarachnoidal hemorrhages.
GRHL3 -/- mice demonstrated defects in cell migration.
All mice demonstrated hyperactivity during housing.
Opn4 DTA/DTA ipRGC ablation mice demonstrate a significant increase in the overlap projections to the dLGN, leaving the ipsilateral and contralateral projections similar to those in the wild-type mice.
Overall survival of 5 of 6 ixazomib-treated mice doubled compared with mice left untreated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com