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We therefore were surprised to find that >80% of Smad3+/−; Rab25−/− mice demonstrated large invasive colon tumours throughout the colon by 15 weeks of age.
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While 10 weeks of control diet did not affect any of the above parameters, OCR mice demonstrated a large decline of LVMI, falling to a level comparable to YCL young mice and significantly lower than that of OCL mice (P < 0.001, Fig. 2A).
PLT-depleted tumors demonstrated large dark cores, associated with increased hemorrhagic areas, while 4 tumor-bearinging platelet-depleted mice exhibited a significant reduction in lung metastasis compared to control mice (Additional file 1: Figure S1B).
These results clearly demonstrated large LYVE-1+ lymphatic vessels compared with smaller CD31+ vessels in the pannus of TNF-Tg mice.
In vivo, orthotopic implantation of Cav-1-secreting mouse prostate cancer cells into mice demonstrated that tumors are both larger and more vascular in Cav-1 versus Cav-1 recipient hosts, although tumor-associated endothelial cells in Cav-1 mice demonstrated uptake of tumor-derived Cav-1.
In addition, quantitation of histology sections demonstrated larger cardiomyocytes in the HFD B6 mice compared to their CD counterparts.
Most infected mice demonstrated infiltration of the walls of large blood vessels with extensive clusters of parasites in the myocytes of the muscular stratum and accompanied by an inflammatory reaction, interstitial edema, and rupture of muscle fibers [ 52].
Conversely, the mice exhibiting lower levels of bioluminescence at earlier time points demonstrated larger tumor volumes at the end of the experiment.
In vivo cardiac MRI studies demonstrated larger right ventricular end-diastolic and end-systolic volumes and lower right ventricular ejection fractions in mdx mice [ 88].
Another postulated mechanism from a study in mice demonstrated that insulin causes megakaryocytes to produce larger platelets (29).
Another postulated mechanism from a study in mice demonstrated that insulin induces megakaryocytes to produce larger platelets [ 28].
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