S. pneumoniae infected mice demonstrated increased collagen deposition at the pleural and subpleural space when compared to saline-treated mice at 14 days.
S. pneumoniae infected mice demonstrated increased collagen deposition at the pleural surface and in the subpleural region compared to saline-treated mice.
Confocal analyses of tissue sections from S. pneumoniae-infected mice demonstrated increased α-SMA expression that colocalized within the pleural and subpleural regions, demonstrating that MesoMT occurred in WT mice by 7 days after pleural infection.
Following sulfur mustard exposure, primary skin fibroblasts from PARP-deficient mice demonstrated increased internucleosomal DNA cleavage, caspase-3 processing and activity, and annexin V positivity, compared to those derived from PARP+/+ animals.
βOGT-KO mice demonstrated increased ER stress and distended ER architecture, and these changes ultimately caused the loss of β cell mass due to ER-stress-induced apoptosis and decreased proliferation.
However, the immunohistochemical staining of frontal cortex from 15-month old knock-in mice demonstrated increased TDP-43 and ubiquitin-positive inclusions.
Instead, IL-10 promoted retinal angiogenesis by altering macrophage angiogenic function, as macrophages from wild-type mice demonstrated increased vascular endothelial growth factor (VEGF) and nitric oxide (NO) compared to IL-10 deficient macrophages.
Additionally, in vitro, T cells from PTPN13-deficient mice demonstrated increased differentiation into T helper-1 (Th1) and T helper-2 (Th2) subsets that synthesize the cytokines interferon-γ (IFN-γ) and IL-4 respectively [27].
Consistent with weight measurements, histology of cardiac tissue and cross sectional area measurements from postnatal Tpr-Met mice demonstrated increased ventricular cardiomyocyte size, compared to controls (p<0.005; Figure 5D,E and Figure S4).
129/Sv mice demonstrated increased blood pressure, glomerulosclerosis and interstitial fibrosis in comparison to C57BL/6 mice.
