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Similarly, exendin-4-treated mice demonstrated improved systolic function post-MI, reflected by higher ejection fraction and lower LVESV.
The TPO knock-in mice demonstrated improved engraftment of human CD34+ hematopoietic and progenitor cells, especially in bone marrow, and long-term maintenance of chimerism for over 6 months.
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SAG1.1 treated mice also showed improved hippocampal long-term potentiation and correction of learning deficits in the Morris water maze compared with untreated mice, demonstrating improved hippocampal function in response to transient Hh pathway activation.
Administration of leptin to ob/ob or C57BL/6J mice demonstrates improved hepatic insulin sensitivity and decreased fasting glycemia and body weight (Halaas et al., 1995; Pelleymounter et al., 1995).
Our results were similar to the findings of a study showing that knockout mice lacking TNF-α expression demonstrated improved IR [ 56], and they were consistent with recent studies showing beneficial effects of anti-TNF-α therapy on IR [ 24, 52].
In a lipopolysaccharide (LPS) sepsis model, Tsutsumi et al. demonstrated that mice on a whey-based diet demonstrated improved survival with less mitochondrial autophagy and improved mitochondrial bioenergetics compared to mice on a casein-based diet [42].
In a lipopolysaccharide (LPS) sepsis model, Tsutsumi et al. demonstrated that mice on a whey-based diet demonstrated improved survival with less mitochondrial autophagy and improved mitochondrial bioenergetics compared to mice on a casein-based diet [ 42].
Intraperitoneal glucose tolerance test performed on day 208 demonstrated improved glucose tolerance of LeMSCAFF mice compared with LeGFPFF mice.
The authors demonstrated improved efficiency of such UI compared to a two-button mouse interaction [35].
hCNS-SCns transplanted mice demonstrated significantly improved locomotor recovery compared to vehicle controls using open field locomotor testing and CatWalk gait analysis.
Our results conclusively demonstrate improved therapeutic efficacy when wt-p53 gene is administered into the tumor bearing mice in combination with gemcitabine.
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