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The VLP-vaccinated mice demonstrated high antigen specific antibody titers and effective cellular immune responses.
In contrast, earlier studies in mice demonstrated high levels of BCRP and MDR1 expression in normal hematopoietic stem cells [ 31– 31].
In fact, recent studies in PINK1 null mice demonstrated high levels of TGFβ1 and susceptibility to pulmonary fibrosis (Knight et al., 2003; Bueno et al., 2015).
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The capacity of NEP to proteolyze Aβ was further confirmed by findings that NEP-deficient mice demonstrated higher cortical Aβ levels than wild-type ones, and human Aβ was more slowly degraded when injected into NEP-deficient mouse brains than into corresponding wild-types [11].
As determined by SPR analysis (Table 1 and [41]), the Mabs derived from the heterologous regimen (ES5 primed, ES1 boosted) mice demonstrated higher affinity to the conformational probes (ES4 and ES2) than the Mabs generated from the homologous regimens of ES5 alone or ES1 alone.
Interestingly, Tregs from B6 mice demonstrated higher suppression of CD8+ T cell killing than Tregs from NOD mice.
EP-treated mice demonstrated higher serum AST and impaired hepatocyte regeneration at the 48-hour time point.
Consistent with increased thermogenesis, sensors implanted onto upper flanks of mice demonstrated higher daytime core body temperature.
Indeed, hypercholesterolemic patients administered CRP exhibited augmented procoagulant responses (24), and hCRPtg mice demonstrated higher incidence of the prothrombotic phenotype (39).
(E ) SCH23390-infused mice demonstrated higher and lower c-Fos+ cell density in the ventral intercalated amygdala neurons (ITCv) and the central nucleus of the amygdala (CeM), respectively (n = 7 8 mice; ITCv: t (13) = 3.0, p = 0.0093; CeM: t (14) = 2.9, p = 0.011).
As expected, immunohistochemistry of lungs in homozygous Rosa26R-Sox2-IRES-GFP mice demonstrates high levels of recombination as measured by GFP expression and Sox2 protein within the conducting airways, BADJs and the alveolar tumors (Fig. 7A C).
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