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Furthermore, flow cytometry using whole blood from P2Y12-deficient mice demonstrated complete inhibition of αIIbβ3 activation in response to ADP and of P-selectin expression in response to low convulxin (Fig. 3C).
Fifty percent (three out of the six) of treated mice demonstrated complete regression of residual tumor.
Our previous results [ 8] wherein we have used SP precursor knockout mice demonstrated complete reversal of manifestations of murine viral-myocarditis, whereas our current studies using pharmacological inhibition showed reduction, although significant but not complete prevention of the manifestations.
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R49Cneo/R49Cneo mice demonstrated nearly complete lens opacities by 5 months of age.
For example, 2nd generation HPMA copolymer-epirubicin (EPI) conjugates (2P-EPI) demonstrated complete tumor regression in the treatment of mice bearing ovarian carcinoma.
This study demonstrated complete protection against infection by homologous parasites in rats or mice immunized with non-viable oncospheres of H. diminuta and H. nana, respectively.
Nine patients demonstrated complete wound healing.
All implants demonstrated complete osseous ingrowth.
ADAM17-null mice demonstrating essentially complete abrogation of L-selectin shedding by their leukocytes were used in this study.
The main differences between the pathologies of the Atoh7-deficient mice and human patients with homozygous ATOH7 mutations described in this study are that the mice failed to demonstrate complete retinal detachment and any obvious anterior segment abnormalities were absent (7, 8).
Comparative analysis of KO and humanized mice demonstrated differential effects of complete and partial inhibition of S1PL activity on general physiology versus immune function.
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