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Knockout FVII mice demonstrated a delayed prothrombin time and decreased plasma FVII expression.
The authors report that the mice demonstrated a human innate immune response that is essential for early response to foreign invaders.
Unbiased microarray analysis of microglia isolated from adult Cd11bCre EP2 lox/lox) and control mice demonstrated a broad downregulation of inflammatory pathways with ablation of microglial EP2 receptor.
Moreover, although all groups displayed similar saline-CPP, Tat-induced GT-tg mice demonstrated a three-fold increase in cocaine-CPP over the response of either uninduced littermates or Dox-treated C57BL/6J control mice.
Finally, the combination of AR-42 and gemcitabine in transgenic mice demonstrated a significant increase in survival than either agent alone.
Capsules subcutaneously implanted in DBA/2J mice demonstrated a tightly regulated secretion of EPO through up to four on off cycles during a period lasting 40 weeks.
Lens epithelium in PAR39 transgenic mice demonstrated a decrease in the percentage of BrdU/DAPI staining within the GZ as compared to nontransgenic littermate controls (8.1% vs. 10.9%).
C57BL/6 mice demonstrated a distinct profile of microbiome file in gut.
Diabetic E4LDLR mice demonstrated a decreased reliance on lipid as an energy source based on indirect calorimetry.
In addition, OX40 ligand-deficient mice demonstrated a decreased risk of allograft rejection when transplanted with wild-type donor corneas.
Characterization of the deficient mice demonstrated a diminished level of peanut agglutinin+ germinal centers and a failure in isotype switching despite normal B cell signaling in vitro.
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