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Of interest is that we have recently reported that ADAM17-null mice demonstrate enhanced host resistance, including decreased hematogenous spread of bacterial to the lung, during E. coli-mediated abdominal sepsis [22].
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Of interest was the observation that SCID mice demonstrated enhanced protection following transfer of additional doses of rabbit J8-DT IgG.
Similarly, Akt was also activated to a greater extent in response to insulin in WAT and BAT from Mstn−/− mice compared to control mice demonstrating enhanced in vivo insulin signaling in mutant skeletal muscle and adipose tissues.
While mDCs from allergen-challenged A/J mice demonstrated enhanced capacity for allergen uptake (compared to those from C3H mice), fewer mDCs were present in the lungs of A/J animals, suggesting that genetic differences associated with susceptibility to allergen-induced AHR govern the function of distinct DC subsets, and not their selective recruitment.
Hyperinsulinemic MKR+/+ female mice demonstrated enhanced mammary gland ductal branching and increased lateral bud formation.
Conversely, SREB2 KO mice demonstrated enhanced performance in this task at delays at which the WT mice showed random alternation.
The exogenous glucose infusion rate required to maintain euglycemia under clamp conditions was markedly higher in FGF21-Tg mice than in wild-type mice, demonstrating enhanced whole-body insulin sensitivity.
APChigh-mice demonstrated enhanced susceptibility to B. pseudomallei infection compared with WT mice as indicated by a strongly increased mortality accompanied by enhanced bacterial loads in the lungs, blood, and distant organs 48 hours after infection [ 22].
Compared with lean mice, obese mice also demonstrate enhanced increases in airway inflammation and airway responsiveness after exposure to ozone, a common asthma trigger (Rivera-Sanchez et al. 2003; Shore et al. 2003).
We also show that both insertion mutants demonstrate enhanced tumorigenicity in nude mice.
These observations demonstrate enhanced islet β-cell proliferation post-PX in Cdk4R/R mice.
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