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HNF4A knockout mice demonstrate altered cholesterol and triglyceride profiles [10], whereas studies of these parameters in human HNF4A-MODY patients have been conflicting [11], [12].
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We found that the 4E-BP2 knockout mice demonstrated altered activity in the rotating rod test, light/dark exploration test, spontaneous alternation T-maze and conditioned taste aversion test.
Primary cells derived from Fmn1-IV knock-out mice demonstrated altered processive behavior at the cell periphery coupled with a delay in cell spreading and altered focal adhesion formation.
In response to infection, mice demonstrated altered hepatic immune function and reductions in urea cycle enzyme activity and urea cycle intermediates.
In addition, Usp2 KO mice demonstrated altered light-induced resetting of the clock (Fig. 2), indicating an involvement of USP2 in light-dependent signaling pathways in the SCN.
Indeed, classical models of human breast oncogene overexpression in the mouse mammary gland demonstrate altered biological processes responsible for proper ductal and alveolar development, as well as modified initiation and execution of glandular involution [ 26].
We therefore conclude that mice with netrin-1 insufficiency do not demonstrate altered neuronal patterning during DSS.
Additionally, at least two, TRIM27 and TRIM23, demonstrate altered expression in Ataxin-7266Q/+ Ataxin-7266Q/+omoused with wild-type litteretina.
There are approximately 20 additional proteins that demonstrate altered expression patterns in the absence of CSPα in mice [ 13] that can also be part of its pathogenic cascade.
Transgenic mice that express a truncated form of bone morphogenetic protein receptor type II (BMPR2) demonstrate altered expression of 181 unique named genes [17].
Interestingly, we could not demonstrate altered systemic insulin-like growth factor-1 levels in our hormone-treated mice at 4 weeks after hormone removal (D Medina and A Lee, unpublished data).
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