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Here we describe a distinct line of INI mice, created on a C57BL/6 genetic background, to examine the consequences upon neuroendocrine and behavioural phenotypes associated with dysregulated 5-HT2C receptor signalling.
This difference in the number of H-2q versus DR4 restricted epitopes from CII may help to explain why these DR4-IE transgenic mice (created on the collagen-induced arthritis resistant C57BL/6 background) are resistant to collagen-induced arthritis [ 30].
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Weinstein and J.B. Wang, were obtained from hybrid mutant mice, originally created on a 129SvJ-C57BL/6 byckground, backcrossinging mice from the 129 strain for several generations.
Additionally, it should be noted that the KO mice were created on a Black Swiss strain background.
Gria1−/− mice were created on a hybrid C57BL/6/129sv background (Zamanillo et al., 1999).
Because the mice were created on a mixed C57/129 background, we cannot rule out the possibility that alleles from the 129 strain, as opposed to the gene knockout, are causing the differences in phenotype.
Papaleo et al. also found impairments in several cognitive measures, including attentional set shifting and working memory in COMT-Val-tg overexpressors, compared with wild-type controls, although these mice were created on a mixed genetic background.
The Lrp5 −/− mice were created on a C57BL/6J background by generating an allele that disrupts the extracellular domain of Lrp5 by inserting an IRES-Lac-Z/Neomycin cassette at amino acid 373 [15].
The mice created antibodies in response to the vaccine.
In Orchestra Da Camera (above), mice create a symphony by running on the always-metaphorical hamster wheel.
However, using live mice creates the need for a lot of extra effort on your part.
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CEO of Professional Science Editing for Scientists @ prosciediting.com