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The long term observation of rare polyp initiation in some of the Hnf4α mutant mice could suggest that cumulated defects associated with colonic crypt distortion could eventually lead to tumor initiation under specific circumstances.
The association between tau aggregation and pTDP-43 cytoplasmic aggregation in these tau transgenic mice could suggest that tau is the most critical factor driving TDP-43 aggregation in human DLB.
A decline in IGF-1 expression occurs with age progression (Hammerman, 1987), and high IGF-1 levels in the 2 year old AAV9-mTERT treated mice could suggest an improved health-span.
However, the decreased time of latency of first move into the light-half in the light-dark paradigm shown by Scn8a Clth /Scn8a Clth mice could suggest that these mice show lessened anxiety.
The fact that at low-frequency stimulation, quantal content values were increased in the ASIC1a −/− mice could suggest the existence of a basal concentration of protons at the neuromuscular synaptic cleft resulting from the spontaneous release of synaptic vesicles.
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Here, we demonstrate significant alterations in mPFC GS-IR astrocytes already at the age of 1 month, when no Aβ is detected, and decreased GS protein expression manifested from 6 months onwards in 3xTg-AD mice, which could suggest ongoing metabolic pathology.
The discovery may help explain why humans evolved more elaborate brains than mice, and it could suggest ways to treat disorders such as autism and epilepsy that arise from abnormal neural development.
Our observed increase in the anti-apoptosis marker Bcl-2 in the MuRF1 KO mice with age could suggest a mechanism to protect the muscle from the apoptotic affects of increased caspase-3.
The observed poor transcriptional alteration in the brain of mouse depleted for PrP could suggest that these animals adapted to this genetic environment during embryogenesis.
One could suggest that reduction of those mediators might contribute to wound healing impairment observed in HO-1 deficient mice.
The commission could suggest new reforms.
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