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Therefore, the opposite pattern seen in CXCR5-deficient mice could reflect the inability of their myocardial fibroblasts to respond to CXCL13.
The lower amount of TGF-β in TLR2−/− mice could reflect the reduced TLR2-dependent synthesis of this factor by TECs, macrophages, and interstitial fibroblasts.
The presence of abnormal electromyography patterns together with the observed morphological changes in the postsynaptic apparatus from old MCK-UCP1 mice could reflect denervation.
Our observation that the egg burden is reduced in both OBF-1-deficient mice and µMT mice could reflect an effect of a B cell deficiency on egg-laying during early infection.
The delayed lipolysis of plasma triglycerides in Col18a1−/− mice could reflect deficiencies in various factors involved in Lpl-mediated turnover, including angiopoietin-like 4 [27], caveolin-1 [28], and apolipoprotein C-II [29].
The apparent disparity in the results between the Axl−/− mice and the Gas6−/− mice could reflect the ability of alternate members of the TAM receptor family to compensate for the loss of Axl, whereas the overall reduction in signalling that accompanies the loss of an important ligand could outstrip the ability of, for example, ProS to compensate for this loss.
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The relative instability of the mouse gut microbiota observed here may be a biological property of mice or could reflect environmental (specific pathogen free housing conditions) or biological (inbred populations) aspects of our experimental design.
Trees with TNF were problematic because they confused resistant with supersusceptible DO mice, which could reflect the different roles of TNF as a resistance requirement and disease correlate in inbred mice and humans (Law et al., 1996; Bekker et al., 1998, 2000; Juffermans et al., 1998; Ray et al., 2009; Fallahi-Sichani et al., 2010), and in DO mice (Table 1).
The low levels of antibodies detected in the mouse sera could reflect the degree of infectious virus that is presented to the immune system in these inbred mouse strains.
Differences in NHEJ between mice and man could reflect the fact that human (stem) cells reside for much longer periods in a dormant G0 or G1 state of the cell cycle compared with their murine counterparts.
Within-mouse transcript variation could reflect stochastic variation in gene expression, which has been observed within individual cells and across cell populations [ 13- 20].
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