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Next, the team looked at whether different rates of neurogenesis between adult and infant mice could explain the young rodents' forgetfulness.
The lack of T cell priming, expansion and migration in the C3−/− mice could explain the delayed viral clearance.
This is of particular importance, since general locomotor activity differences between mice could explain alterations in anxiety tests.
This convergence between normal mice exposed to long-term CR and innately insulin-sensitive GHRKO mice could explain why CR fails to further improve insulin sensitivity of GHRKO mutants or further extend their already-long lives.
Differences in permeability between the intestinal epithelium of adult and neonatal mice could explain why, in adults, the immune cells of the lamina propria were less accessible to orally administered CpG-ODN, leading to a weaker intestinal chemokine response both in wild-type and IL10 KO mice.
The low content of Pt in the kidneys of DWA2114R-treated micoulduld explain its lower nephrotoxicity.
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Apo-E KO/CKD mice present higher calcification and atherosclerosis levels than WT CKD mice; this could explain why we did not find an increase in WT CKD mice for miR-126 expression.
There were no differences in total collagenolytic activity between wildtype and knockout mice, thus discarding an overcompensatory increase of other collagenolytic enzymes in Mmp8−/− mice that could explain the decreased fibrosis (Figure 3B C).
Tc1 mice have many more orthologs of chromosome 21 genes in three copies compared with Ts65Dn mice, which could explain their more pronounced motor impairment.
This does not exclude the hypothesis of an epigenetic and silencing defect of the paternal X chromosome in those mice, which could explain the sex-ratio distortion observed.
These results indicated that these six H9N2 isolates were all able to replicate systemically in mice, which could explain the high lethality observed in the high dose (107 EID50 and 106 exposurexposure groups.
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