The crosstalk between the dendritic cells and natural killer cells pathway has been related in other studies to be one of the responsible alterations found in NOD mice that could elicit T1DM [ 37, 38].
Because BbCRASP-2 is surface-exposed [17], immunogenic, and expressed throughout the murine infection, we next assessed if immunization of mice using recombinant BbCRASP-2 could elicit protective immunity and influence the outcome of Lyme disease.
Taken together, our study in HLA-DR1 and -DP4 transgenic mice revealed that HCV F protein could elicit HLA-class II restricted CD4+ T cell response in vivo.
A year later, Voll's [ 7] group demonstrated that the injection of nucleosomes from apoptotic cells could elicit lupus in mice, and implicated a role for HMGB1-bound nucleosomes in this process.
This study indicated that native but not recombinant HSP16 (when administered with the adjuvant dioctadecylammonium bromide) could elicit protection in a mouse model of TB, and in addition, it had the capacity to boost an existing BCG vaccination.
To determine whether intranasal H5N1 VLP vaccination could elicit protection against lethal infection, immunized mice were challenged with a highly lethal dose (100 50% mouse lethal doses [MLD50]) of the wild type VN/04 virus at 30 weeks after the boost immunization (Fig. 5).
These data indicate that two closely related strains of S. aureus could elicit very different inflammatory responses in mice mammary tissue.
Re-exposure to the light compartment could elicit fear memory without giving the mice the opportunity to acquire extinction of the dark compartment memory.
Then, we found that only pr4 19-34aaa) could elicit high-titer antibodies in Balb/c mice, and this epitope could react with sera from DENV2-infected patients, suggesting that specific antibodies against epitope peptide pr4 were elicited in both DENV-infected mice and human.
