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Overexpression of Beclin-1 in mice could develop excessive autophagy to prevent tumor development [ 9].
Lack did part of his training in pediatric allergy at the National Jewish Medical and Research Center in Denver, where he discovered that mice could develop allergies to a particular egg protein that was first rubbed on their skin or inhaled before they had ever eaten it.
In the current study, we showed that the iSG, which connected to the nerve fibres derived from recipient mice, could develop into the correct gland structure following orthotopic transplantation in association with the parotid duct and could produce saliva by muscarinic receptor-mediated stimulation as well as gustatory stimulation by citrate.
Additionally, muMT B cell-deficient mice could develop the arthritic disease to the same extent as WT animals.
However, we cannot totally rule out the possibility that the mice could develop the disease later in life, most probably beyond 15 months of age; unfortunately in these studies we never kept our mice beyond this age.
Germ-free mice could develop oral tolerance if the gut flora was reconstituted with Bifidobacterium not later than during the neonatal period.
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We wanted to further investigate whether the mice encountered stress could develop to NASH.
Noce's team showed that germ cells (derived using techniques similar to Daley's) transplanted into the testes of adult mice could apparently develop into mature sperm.
In contrast, around 40% of MMTV β-TRCP1 transgenic mice targeting the epithelial tissues could develop tumors including mammary, ovarian and uterine tumors, indicating that β-TRCP1 could promote epithelial tumorigenesis in vivo (Kudo et al., 2004).
Here, Chen et al. report the results of experiments which showed that mice with an inactive Sec24a gene could develop normally.
Although Tfh cells could develop in these mice, there was a reduction in the GC compartment size the percentage of plasma cells and, importantly, the amount of antigen-specific antibodies following immunization.
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