The researchers kept lowering the concentration of the chemicals to see if the mice could detect, and therefore avoid, it.
We started by asking whether mice could detect a simple luminance step by switching one of the monitors to "white" after the animals had been allowed to explore the box for several minutes with both monitors set to "black".
To probe temporal resolution of the restored vision, we investigated whether treated mice could detect the transition from a gray to a flickering screen of equivalent time-averaged irradiance (0.066 W/m).
Interestingly, while C3 was almost undetectable in both groups of recipient WT mice, we could detect comparably abundant C3 deposition in recipient Stat3C/C mice transplanted with either WT or Stat3C/C BM cells, correlating with their failure to survive.
In the tissue sections of arthritic mice, we could detect inflammatory infiltration in the synovium and articular cavity, synovial hyperplasia, pannus formation, bone and cartilage erosions, and furthermore proteoglycan loss was clearly evident.
However, developing a GM mouse that could detect them would not be a trivial task – researchers would first have to identify the neurons in the mouse's olfactory bulb that detected the TB odour in question (from the millions of possibilities in the mouse's nose) and then identify and modify the correct parts of the genome to create their desired biological sensor.
Similarly, while TorsinA was found to be a potent suppressor of α-synuclein aggregation and toxicity in cellular models [ 79] and in a Caenorhabditis elegans model [ 93], an elegant recent study using both an MPTP-induced mouse model of PD and α-synuclein transgenic mice could not detect a neuroprotective effect for overexpression of TorsinA [ 94].
Sand fly and RD cells as well as mice and embryonated eggs could detect the virus down to 1.2 × 102 PFU/ml.
Thus, neither the first or second wave of H2AFX modification normally occurring during leptotene followed by sex chromosome specific enrichment during pachytene, respectively, could be detected using multiple commercially available antibodies which could detect mouse meiotic H2AFX in our hands.
To verify whether Trpm5 −/− mice with dysfunctional MCH neurons could detect the post-ingestive effects of sucrose, we adapted a conditioning protocol as in de Araujo et al. (2008), that allows the animal to manifest taste-independent preferences (scheme in Figure 5).
They watched for this activity by opening a small hole along the spine of the mouse through which a microscope could detect when the nerve cells lit up.
