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A decade ago, however, neurobiologist Frederick vom Saal's group at the University of Missouri, Columbia, reported that even very low levels of this so-called endocrine disruptor fed to pregnant mice could cause changes in the prostate glands of their male offspring.
While we cannot directly link changes in glutamate receptor editing to susceptibility to KA, we speculate that altered mRNA editing and expression of glutamate receptors in COX-2−/− mice could cause an imbalance in the interplay between AMPA and NMDA receptors and alterations in glutamatergic neurotransmission.
Different tissue isolation procedures and/or different age or body weight of mice could cause differences in the basal levels of AA metabolites.
Secondly, the double dose of X genes in XX mice, relative to XY mice, could cause constitutively higher expression of some X genes [ 59].
Based on the above results one might speculate that the increased pericyte coverage of the tumor vasculature observed in D849N-mutant mice could cause accelerated establishment of tumors due to improved vessel function.
Although decreased expression of PinX1 was observed in breast cancer cell lines, and knockout of PinX1 in mice could cause breast cancer [ 3], the role of PinX1 in growth control of breast cancer cells and its molecular mechanism remains unclear.
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Who would have guessed that a simple keystroke and a click of the mouse could cause so much harm?
Finally, these six H9N2 viruses were highly lethal to mice and could cause 100% mortality without prior adaptation after exposure to 107 EID50 of virus.
Lai et al. [ 9] reported that induction of IL-1β in healthy mouse joints could cause joint structure changes, dysfunction, and pain.
This may due to the large doses of CFA (50 μg) and IFA (50 μg) used in mice immunization, which could cause greater side effects than CpG ODNs.
We have used 5-week-old mice to elucidate pathways and factors underlying the early islet proliferative response that might have failed in the POKO mice and that could cause the inadequate β-cell expansion in this model.
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