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(b) Representative immunoblots of AHR (upper panel) and GAPDH (lower panel) in total protein lysates of BMDMs from WT and AHRLysM mice, corresponding to the immunoblot in the Supplementary Fig. 3b.

(d) Immunoblots of TRAF6 (upper panel) and GAPDH (lower panel) in total protein lysates of BMDMs stimulated or not with TCM for 6 hours from WT and AHRLysM mice, corresponding to the immunoblot in the Supplementary Fig. 4k.

(c) Western Blot analysis of NF-κB (p65) (upper panel), GAPDH (middle panel) and histone 3 (lower panel) in cytoplasmatic and nuclear fraction of BMDMs stimulated or not with TCM for 90 minutes from WT and AHRLysM mice, corresponding to the immunoblot in the Fig. 4l.

These absorbed doses were lower than the MTD of 25 MBq 213Bi-DOTA-AMBA in PC3-tumor-bearing mice, corresponding to the MTD at a mean absorbed dose of 4 Gy in the blood [31].

Copper and iron levels were significantly increased in brains of 12-week R6/2 HD mice, corresponding to late-stage HD.

However, only iron was increased in the brains of 12-month CAG140 HD mice, corresponding to pre-clinical HD (Figures 4A D).

Right images are the PET and fDOT signals rendered to the envelope of the mouse corresponding to the sagittal (G), coronal (H) and axial (I) projections.

In addition, one mouse corresponding to the group treated with telmisartan did not develop any tumour.

This yielded 2616 up- and 2305 down-regulated MaSC signature probes in mouse, corresponding to 3410 unique gene symbols, of which 2754 had human orthologs.

Using our computational cross-species hybridization algorithms and the initial biologic experiment (Methods, 5% threshold CSH), we identified 4,259 commercial probes as cross-hybridizing (2,104 human, 2,155 mouse) corresponding to 3,550 distinct genes.

We identified a single major serine phosphorylation site in that study (S220 in the mouse, corresponding to S228 in the human protein) that was a substrate for MAP kinases both in intact cells and in cell-free systems.