These results indicate that the use of HLA A∗0201/DR1 Tg mice constitute a versatile model system (in lieu of immunizing humans) for the study of both HLA class I and class II restricted T-cell responses.
The finding that high-fidelity genotypes of an RNA virus have lost some of their adaptive properties in mice constitutes a strong support of this hypothesis [35], [36].
Taken together, our experiments show that subretinal MPs observed in Cx3cr1−/− mice constitute a significant degree of monocyte-derived MPs recruited from the bloodstream and seem to have an important role in the induction of photoreceptor cell death.
Col4a1 and Col4a2 mutant mice constitute a valuable tool for further understanding the biological importance of allelic differences on the variable expressivity of disease caused by mutations in genes encoding type IV collagens.
The humanized murine models (mice carrying functioning human genes), generated by introduction of MHC, T-cell receptor (TCR), and costimulatory genes from humans into NOD/severe combined immunodeficiency disease (NOD/SCID) mice, constitute a great value for better understanding certain unexplored aspects of the human condition.
All these studies have confirmed the important role of Treg cells in the control of diabetes onset and progression, and that a decrease in CD4+Foxp3+ Treg cell frequencies or function in NOD mice, constitutes a critical predisposing factor to T1D [ 15].
The ability to generate teratoma in immunodeficient mice constitutes an important test of pluripotency.
These mice constitute an important new model in which to study future therapies and outcomes of this complex disease.
Thus, our conditional Gαo-mutant mice constitute an appropriate model to examine the role of Gαo-expressing VSNs in pheromone-stimulated behavioral responses of female mice.
To address whether bone marrow is affected in the course of arthritis, human tumor necrosis factor transgenic (hTNFtg) mice, constituting an established animal model of human RA, were examined for bone marrow changes.
