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The chimeric WldS gene resulted from a spontaneous mutation in the C57BL/6 line of mice, causing a tandem triplication in the distal region of chromosome 4 [20].
This result may reflect the homeostatic imbalance in Fg-deficient mice, causing a general increase in sensitivity to infection [33], [34].
Despite this unanticipated phenotype, Brca1-deficiency in these tumors influenced the survival time of the mice, causing a significant reduction in the length of survival of p53 and p53/pRb-deficient mice, compared to the mice without Brca1 deficiency.
H. hepaticus selectively colonizes the hepatic bile canaliculi of mice, causing a morphologically distinctive pattern of chronic active progressive hepatitis, and also persistently infects the large bowel.
Occasionally, we have observed axial dystonia to either side of L-DOPA-treated MitoPark mice, causing a loss of equilibrium and animals rolling over.
The degree of methylation and corresponding level of ectopic Agouti expression vary stochastically among individual isogenic A vy/ a mice, causing a wide variation in coat color ranging from yellow (unmethylated) to pseudoagouti (methylated) (Morgan et al. 1999).
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Once again, stress produced paradoxical effects in doubleridge mice, causing an increased proliferation of neuroprogenitors, as detected by both dot-blot analysis (Figure 5A) and BrdU immunostaining (Figure 5B).
Encouragingly, intracerebroventricular injection of 28 into amyloid precursor protein (APP) transgenic mice caused a 29% reduction of Aβ1 40 production.
Our results showed that exposure of MC in NAFLD mice caused a significant increase in mesangial cell activation as evidenced by increased a-SMA in the extracellular matrix surrounding the glomeruli.
A year and a half ago, the engineered mice caused a media stir, when their creators at Princeton University reported in Nature that they outperformed their normal counterparts on a variety of learning and memory tests (ScienceNOW, 1 September 1999).
However, IL-7 depletion in KO mice caused a significant decrease of Bcl-2 MFI in CD8+CD44int/hi CD127hi T cells.
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