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UPLC-qTOF/MS analysis showed that co-administration of SSPS and genistein in mice caused significant elevation in the urinary levels of genistein and its metabolites (p < 0.05).
Reducing the function of Atg16L1 in mice caused significant changes to specialized gut epithelial cells, called Paneth cells.
Studies have shown that LPS injection in mice caused significant inflammatory damage (such as biochemical and histological damage in lung and liver) [ 23, 35].
The xanthones extract, when fed to nude mice, caused significant growth inhibition of the subcutaneous tumor of HCT 116 colorectal carcinoma cells.
The administration of CDDP (100 μg/kg bw) to mice caused significant increase in blood levels of creatinine and urea and decreased significantly blood levels of albumin and total protein.
We found that oral administration of thiram (30 μg) to mice caused significant inhibition of C6 glioma tumour development (60%) and marked reduction (by 3 5-fold) in metastatic growth of Lewis lung carcinoma.
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MCMV brain infection of newborn mice causes significant loss of NSCs, decreased proliferation of neuronal precursor cells, and marked loss of young neurons.
In conclusion, we found that MCMV brain infection of new born mice causes significant loss of NSCs, decreased proliferation of neuronal precursor cells and loss of young neurons expressing DCX.
Since the lymphoid tumors that arise in Tax mice cause significant bone loss (osteolysis) [15], [16], we hypothesized that crossing Arf-/ mice (prone to accelerated bone remodeling) with Tax mice (prone to osteolytic malignancies) would exacerbate tumorigenesis and tumor mediated osteolysis.
Scratching the skin of mice causes significant mast cell degranulation within minutes [ 74].
Specific IFN-γ and IFN-β-induced IDO activation in mouse and human MSCs caused significant changes at the transcriptional and protein level of neural, adipocytic and osteocytic markers after differentiation induction procedures.
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