Sentence examples for mice caused abnormal from inspiring English sources

On a more subtle level, loss of GABAAR-mediated synaptic inhibition in Purkinje cells of PC-Δγ2 mice caused abnormal patterns of simple spikes, strongly compromising cerebellar learning [17].

Infusion of 3-MT at this behaviorally active concentration (Figure 1A) to saline pre-treated DDD mice caused abnormal movements as evidenced by significantly increased horizontal activity counts in 1 hour period (1097±459 in saline pre-treated 3-MT infused group vs. 50±27 in saline pre-treated vehicle infused controls, * p<0.05; Student's t-test n = 4-6 per group).

Expression of IGFBP-1 is rapidly induced after PH, and the loss of this protein in mice caused abnormal liver regeneration characterized by severe necrosis, reduced and delayed DNA synthesis by hepatocytes, and blunted activation of Erk1/2.

We, therefore, asked whether the deletion of the Snord116 cluster in mice causes abnormal secretion of ghrelin as well.

We previously found that the reduced Prep1 level in hypomorphic Prep1i/i mice caused an abnormal thymic development revealed by an increase of CD4− CDN− DN thymocytes, and a decrease in CD4+ and CD8+ SP cells, mirrored by a lower number of circulating T cells.

More definitive evidence for the involvement of IFT came shortly thereafter, when it was shown that IFT-particle proteins also localized to the connecting cilium and that the same IFT88 mutation that causes PKD in mice (see above) also caused abnormal outer segment development and the death of photoreceptor cells by apoptosis (Pazour et al. 2002b).

In another study, [ 115] it was observed that large vessel remodeling and maturation were abnormal in VEGFR-3 null mice embryos, causing abnormal fluid in the pericardial cavity and resulting in death after E9.5 by cardiovascular failure.

In order to test this, we examined whether genes that when knocked out in the mouse cause abnormal mouse placenta morphology and/or physiology are expressed in the placentas of other eutherian mammals.

In addition, 90 of the 2,963 genes expressed in placentas of human, mouse, and elephant also cause abnormal mouse placenta morphology and/or physiology when knocked out in the mouse.

Sperm from infertile men which consistently fail IVF and ICSI, also fail to induce Ca2+ oscillations upon injection into mouse oocytes, or cause abnormal patterns of Ca2+ release when compared with those of fertile males [ 86, 107].

Large interspecies variability in the phenotypic manifestation of ciliary gene defects is not uncommon; for example, Hydin variants in mice cause hydrocephalus with abnormal motility of the ependymal cilia but PCD in human; similarly, Spag1 variants cause hydrocephalus in fish but PCD in human.