Encouragingly, intracerebroventricular injection of 28 into amyloid precursor protein (APP) transgenic mice caused a 29% reduction of Aβ1 40 production.
Diet restriction in mice caused a significant decrease of noradrenaline, dopamine and 5-hydroxytryptamine (5-HT) in the hypothalamus and hippocampus.
Interestingly, lesions of the adrenal gland in mice caused a pattern of pilocarpine- or pilocarpine-/NE-induced salivary IgA secretion similar to that in sham-operated mice.
Ablation of SGK1 in these mice caused a significant decrease in phosphorylation of SGK1 target protein NDRG1, which correlated with alterations in NF-κB signalling and expression of its downstream target protein, VEGF-A.
Our results showed that exposure of MC in NAFLD mice caused a significant increase in mesangial cell activation as evidenced by increased a-SMA in the extracellular matrix surrounding the glomeruli.
The principal finding of the current study is that administration of a VGLUT1-targeting lentiviral shRNA vector into the dorsal hippocampus of adult mice caused a localized reduction in tonic glutamate release accompanied by selective memory impairments in both nonspatial NOD and spatial Morris water maze tasks.
The oral administration of bis-selenide (25 50 mg/kg) in mice caused a significant increase in the reaction time to thermal stimuli in the hot plate test and the mean ID50 value (and the 95% confidence limits) was 20.37 (15.00 25.74) mg/kg.
Infusion of Ang II to AT2 TG mice caused a significantly attenuated increase in blood pressure response and the change was completely blocked by pretreatment with AT2 antagonist.
Systemic administration of pleiotrophin to irradiated mice caused a pronounced expansion of bone marrow stem and progenitor cells in vivo, indicating that pleiotrophin is a regenerative growth factor for HSCs.
A year and a half ago, the engineered mice caused a media stir, when their creators at Princeton University reported in Nature that they outperformed their normal counterparts on a variety of learning and memory tests (ScienceNOW, 1 September 1999).
Wallenius et al [28] elegantly showed that long-term peripheral IL-6 treatment to Il6−/− mice caused a decrease in body weight.
