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Long-term hyperglucagonemia, as seen with glucagonomas, also causes a T2DM phenotype, and glucagonomas in mice cause a metabolic phenotype characteristic of T2DM [7].
Thus, the decreased SCARB1 protein levels in the liver of Scarb1I179N mice cause a reduction in HDL CE uptake by the liver, leading to a slower CE clearance from plasma and increased HDL cholesterol.
Interestingly, previous studies have shown that reduced γ-secretase and notch1 activity in mice cause a high frequency of skin cancer [ 49] and that hidradenitis suppurativa can be an allelic disorder of early-onset familial AD [ 50].
The mesenchymal defect in the liver of Lhx2-/ mice cause a lethal anemia, which is cell non-autonomous since the Lhx2-/ hematopoietic cells appears to be normal [ 17], suggesting that the mutant microenvironment is unable to support hematopoietic development.
Patients convalescing from typhoid (Neva and Morgan, 1950) and malaria (Rubenstein et al., 1965) are tolerant to LPS, whereas chronic, non-resolving infections, such as caused by BCG in mice, cause a LPS-sensitive Suter (Sutet et al., 1958).
Despite the fact that pregnancy can induce ductal morphogenesis at the late stage of pregnancy, underdeveloped mammary glands in SirT1ko/ko female mice cause a severe deficit in milk production, as shown by histological analysis as well as the immunofluorescence analysis using an anti-milk antibody.
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Myo Va mutations in mice cause an analogous syndrome, the dilute-lethal [dl] phenotype [6].
Interestingly, lesions of the adrenal gland in mice caused a pattern of pilocarpine- or pilocarpine-/NE-induced salivary IgA secretion similar to that in sham-operated mice.
Encouragingly, intracerebroventricular injection of 28 into amyloid precursor protein (APP) transgenic mice caused a 29% reduction of Aβ1 40 production.
McGill University's Dale Langford and colleagues injected acetic acid into the paws of one or both members of a pair of adult mice, causing a painful burning sensation.
Lee, A. W. et al. (NEGR1 Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
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